Hydrazine → HCID 178446160, compound

HRID 1664540Notes

Reaction equation

HRID 1664540 reaction equation
[CH:1]1([C:5]2[NH:13][C:12]3[C:11](=[O:14])[NH:10][C:9](=S)[N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]=3[N:6]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:21][NH2:22]>O>[CH:1]1([C:5]2[NH:13][C:12]3[C:11](=[O:14])[NH:10]/[C:9](=[N:21]\[NH2:22])/[N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]=3[N:6]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 576002418-cyclobutyl-3-pentyl-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one

Product 1

HCID 178446160HCID 178446160, compoundYield 38.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

The mixture of 8-cyclobutyl-3-pentyl-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one (0.6 g, 2.0 mmol) in 20 M of hydrazine in water (20 mL) was stirred at 100° C. overnight. After cooling to room temperature, the solid formed was filtered and dried Cooled down, the solid was isolated to give yield the desired product (230 mg, 38.6%). LCMS calculated for C14H23N6O (M+H): 291.2. found: 291.2.

Workup

  1. temperatureAfter cooling to room temperature
  2. customthe solid formed
  3. filtrationwas filtered
  4. customdried
  5. temperatureCooled down
  6. customthe solid was isolated
  7. customto give

Sources & evidence

ORD record
ord-396063735093497cbadbdcc54c57bac0
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

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