Hydrochloric Acid → HCID 66725663, compound

HRID 1664570Notes

Reaction equation

HRID 1664570 reaction equation
[O:1]=[C:2]1[N:10]2[C:11]([CH2:14][NH:15]C(=O)OCC3C=CC=CC=3)=[N:12][N:13]=[C:9]2[N:8]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:7]2[N:6]=[CH:5][NH:4][C:3]1=2.[ClH:31]>CO.[Pd]>[ClH:31].[NH2:15][CH2:14][C:11]1[N:10]2[C:2](=[O:1])[C:3]3[NH:4][CH:5]=[N:6][C:7]=3[N:8]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:9]2=[N:13][N:12]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57600256benzyl[(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamate

Product 1

HCID 66725663HCID 66725663, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To the solution of benzyl [(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamate (0.30 g, 0.73 mmol) in methanol (20 mL) and 1 mL of conc. HCl was added 10% Pd/C under N2. The mixture was shaken under 30 PSI H2 for 3 hours. The reaction mixture was filtered through celite and concentrated to yield the desired product (210 mg, 92%). LCMS calculated for C12H18N7O (M+H): 276.2. found: 276.2.

Workup

  1. filtrationThe reaction mixture was filtered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-e9f6b7cd71e54d928119dd9ff0a957bd
Source dataset
uspto-grants-2011_10
Patent number
US08039478B2

Reaction notes

Loading…