Aluminium lithium hydride → HCID 67007104, compound

HRID 1664609Notes

Reaction equation

HRID 1664609 reaction equation
[C:1]1(=O)[C@H:6]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:5]2[C:4](=O)[CH2:3][NH:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH2:1]1[C@H:6]2[CH2:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:5]2[CH2:4][CH2:3][NH:2]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 67007225HCID 67007225, compound

Product 1

HCID 67007104HCID 67007104, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (10aR)-2,3,10,10a-tetrahydropyrazino[1,2-a]indole-1,4-dione (200 mg, 0.99 mmol) in 5 mL THF was added LAH. The reaction mixture was refluxed for 1 h. Standard work up afforded 170 mg of pure (10aR)-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indole.

Workup

  1. temperatureThe reaction mixture was refluxed for 1 h

Sources & evidence

ORD record
ord-2ac34ea868884f7a8f1e02c9d508588b
Source dataset
uspto-grants-2011_10
Patent number
US08039471B2

Reaction notes

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