imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester → Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester cyclohexyl-(3-fluoro-phenyl)-methyl ester

HRID 1664643Notes

Reaction equation

HRID 1664643 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[CH:17]1([CH:23]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[CH:26]=2)[OH:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH:17]1([CH:23]([O:24][C:10](=[O:11])[O:9][C@@H:3]2[CH:4]3[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]3)[CH2:2]2)[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[CH:26]=2)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl esterHCID 60798262Cyclohexyl (3-fluorophenyl)methanol

Product 1

HCID 86638970Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester cyclohexyl-(3-fluoro-phenyl)-methyl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with cyclohexyl-(3-fluoro-phenyl)-methanol.

Sources & evidence

ORD record
ord-f32bf8a34d1240078a6b2980555c85ff
Source dataset
uspto-grants-2011_10
Patent number
US08039483B2

Reaction notes

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