Hydrochloric Acid → 2-Hydroxy-4-methoxy-4-oxobutan-1-aminium chloride

HRID 1664831Notes

Reaction equation

HRID 1664831 reaction equation
[ClH:1].[NH2:2][CH2:3][CH:4]([OH:9])[CH2:5][C:6]([OH:8])=[O:7].[CH3:10]O>>[Cl-:1].[OH:9][CH:4]([CH2:5][C:6]([O:8][CH3:10])=[O:7])[CH2:3][NH3+:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21494-Amino-3-hydroxybutanoic acid

Product 1

HCID 866201242-Hydroxy-4-methoxy-4-oxobutan-1-aminium chloride

Procedure

Anhydrous hydrochloric acid gas was bubbled into a suspension of 4-amino-3-hydroxybutanoic acid (0.91 g, 7.61 mmol) in methanol (150 mL) until the solution was saturated and stirred at ambient temperature. After 18 h, the solution was concentrated to give the title compound (1.32 g). MS 134 (M+1).

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-dfbe2ac680bf4df392c030fd0bdc04cf
Source dataset
uspto-grants-2011_10
Patent number
US08039460B2

Reaction notes

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