Hydrochloric Acid → HCID 67439623, compound

HRID 1664925Notes

Reaction equation

HRID 1664925 reaction equation
Cl.[F:2][C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[C@H:10]1[CH2:16][N:15]2[C:17]([CH3:20])=[N:18][CH:19]=[C:14]2[C@H:13]([NH:21]C(=O)OC(C)(C)C)[CH2:12][CH2:11]1>ClCCl>[F:2][C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[C@H:10]1[CH2:16][N:15]2[C:17]([CH3:20])=[N:18][CH:19]=[C:14]2[C@H:13]([NH2:21])[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86620144HCID 86620144, compound

Product 1

HCID 67439623HCID 67439623, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Hydrochloric acid (4.0 M in dioxane; 3.0 mL, 12.0 mmol) was added to a solution of tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-9-yl]carbamate (33 mg, 0.087 mmol) in dichloromethane (3 mL). After 2 h, the reaction mixture was concentrated to give the hydrochloride salt of the title compound. MS 278.1 (M+1).

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-8acc3c6250e245029a9f689ee6c5475c
Source dataset
uspto-grants-2011_10
Patent number
US08039460B2

Reaction notes

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