(4-Fluoro-phenyl)-(4-methyl-piperidin-4-yl)-methanone → HCID 178453897, compound

HRID 1664973Notes

Reaction equation

HRID 1664973 reaction equation
[C:1]([O:5][C:6](=[O:31])[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([C:22](=[O:30])[C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].F[C:33]1C=CC(C(C2(C)CCNCC2)=O)=CC=1.C(OC(=O)N[C@H]1CC[C@H](CC=O)CC1)(C)(C)C>>[C:1]([O:5][C:6](=[O:31])[NH:7][C@H:8]1[CH2:9][CH2:10][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][C:19]([C:22](=[O:30])[C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)([CH3:33])[CH2:18][CH2:17]2)[CH2:12][CH2:13]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 20530715(4-Fluoro-phenyl)-(4-methyl-piperidin-4-yl)-methanoneHCID 178453902HCID 178453902, compound2×HCID 178453924HCID 178453924, compound

Product 1

HCID 178453897HCID 178453897, compound

Procedure

According to the procedure described for the synthesis of Trans-(4-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester (intermediate E, example 1), the title compound was synthesized from (4-Fluoro-phenyl)-(4-methyl-piperidin-4-yl)-methanone and Trans-[4-(2-Oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester. MS (m/e): 447.4 (M+H+).

Sources & evidence

ORD record
ord-12ff893f94854978966fbe3a7fddd590
Source dataset
uspto-grants-2011_10
Patent number
US08039490B2

Reaction notes

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