Trifluoroacetic acid → HCID 178511517, compound

HRID 1664982Notes

Reaction equation

C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([C:22](=[O:31])[C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=3[Cl:30])[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.FC(F)(F)C(O)=O>>[NH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([C:22]([C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:24]=3[Cl:30])=[O:31])[CH2:18][CH2:17]2)[CH2:10][CH2:9]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178453903HCID 178453903, compound

Product 1

HCID 178511517HCID 178511517, compound

Procedure

The title compound was prepared as described on example 1 from Trans (4-{2-[4-(2,5-Dichloro-benzoyl)-piperidin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester and trifluoroacetic acid (m/e): 383.0 (M+H+).

Sources & evidence

ORD record: ord-bfe61be2b864497db8ef085d536af2d7
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08039490B2

Reaction notes

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