HCID 58032833, compound → HCID 66627249, compound

HRID 1665000Notes

Reaction equation

HRID 1665000 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]([C:16]2[S:17][C:18]([F:21])=[CH:19][CH:20]=2)[OH:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CC#N>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([C:16]2[S:17][C:18]([F:21])=[CH:19][CH:20]=2)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 58032833HCID 58032833, compound

Product 1

HCID 66627249HCID 66627249, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

From 4-[(5-fluoro-thiophen-2-yl)-hydroxy-methyl]-piperidine-1-carboxylic acid tert-butyl ester (968 mg) by procedure E.2. MeCN (0.6 ml) was added to the reaction mixture. Yield: 577 mg (60%). Light brown gum. MS (m/z): 336.4 ([M+Na]+).

Sources & evidence

ORD record
ord-11207f7842f849a1be3d3dde3c1bad87
Source dataset
uspto-grants-2011_10
Patent number
US08039490B2

Reaction notes

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