Isobutylamine → N-[(5-Bromothiophen-2-yl)methyl]-2-methylpropan-1-amine

HRID 1665031Notes

Reaction equation

HRID 1665031 reaction equation
[Br:1][C:2]1[S:6][C:5]([CH:7]=O)=[CH:4][CH:3]=1.[CH2:9]([NH2:13])[CH:10]([CH3:12])[CH3:11].[BH4-].[Na+]>CO>[Br:1][C:2]1[S:6][C:5]([CH2:7][NH:13][CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6558IsobutylamineHCID 784285-Bromothiophene-2-carbaldehydeHCID 4311764Sodium borohydride

Product 1

HCID 28428595N-[(5-Bromothiophen-2-yl)methyl]-2-methylpropan-1-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In analogy to example 13, step 1, 5-bromothiophene-2-carboxaldehyde was reacted with isobutylamine and sodium borohydride in methanol to give (5-bromo-thiophen-2-ylmethyl)-isobutyl-amine as a colorless oil.

Sources & evidence

ORD record
ord-0bcae63037d44136a6152554e54972df
Source dataset
uspto-grants-2011_10
Patent number
US08039493B2

Reaction notes

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