HRID1665035

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID137761

2-Fluorobenzenesulphonyl chloride

C6H4ClFO2S

结构：CC(C)CNCc1ccc(-c2cccc(S(C)(=O)=O)c2)s1

HCID67441398

未命名化合物

PRODUCTS

生成物

结构：CC(C)CN(Cc1ccc(-c2cccc(S(C)(=O)=O)c2)s1)S(=O)(=O)c1ccccc1F

HCID25234393

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

In analogy to example 13, step 2, isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine (example 15, step 2) was reacted with 2-fluorophenylsulfonyl chloride in presence of N,N-diisopropyl ethyl amine in dichloromethane to give 2-fluoro-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide as a colorless oil. MS: 499.3 ([M+NH4]+)