HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-chloro-2-fluoro-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Chloro-2-fluorobenzenesulfonyl Chloride | HCID 2778321 | — |
| Reactant | Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine | HCID 67441398 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-chloro-2-fluoro-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide | HCID 25235123 | — |
Reaction Steps
In analogy to example 13, step 2, isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine (example 15, step 2) was reacted with 3-chloro-2-fluorophenylsulfonyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give 3-chloro-2-fluoro-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide as a colorless oil. MS: 532.7 ([M+NH4]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-68c300c5e8694e0e9ac843ff09a01ffe |
| Source note | uspto-grants-2011_10 |