HRID1665054

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

HCID2734658

(Bromomethyl)cyclobutane

C5H9Br

结构：CS(=O)(=O)c1cccc(-c2ccc(CNS(=O)(=O)c3ccccc3C(F)(F)F)s2)c1

HCID67440497

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1cccc(-c2ccc(CN(CC3CCC3)S(=O)(=O)c3ccccc3C(F)(F)F)s2)c1

HCID25234250

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

In analogy to example 10, step 3, N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-2-trifluoromethyl-benzenesulfonamide (example 27, step 1) was reacted with (bromomethyl)-cyclobutane and cesium carbonate in N,N-dimethylacetamide to give N-cyclobutylmethyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-2-trifluoromethyl-benzenesulfonamide as a light yellow semi-solid. MS: 560.7 ([M+NH4]+)