Isobutylamine → 2-chloro-N-isobutyl-benzenesulfonamide

HRID 1665060Notes

Reaction equation

HRID 1665060 reaction equation
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[Cl:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13](Cl)(=[O:15])=[O:14].C(N(CC)C(C)C)(C)C>ClCCl>[Cl:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])(=[O:15])=[O:14]

Participants

5

Reactant 3

HCID 6558IsobutylamineHCID 761872-Chlorobenzenesulfonyl chlorideHCID 81531Diisopropylethylamine

Product 1

HCID 84693762-chloro-N-isobutyl-benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In analogy to example 1, step 1, isobutylamine was reacted with 2-chlorobenzenesulfonyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give 2-chloro-N-isobutyl-benzenesulfonamide as a colorless solid. MS: 248.1 ([M+H]+)

Sources & evidence

ORD record
ord-e3735f44add644689c41b9f549b8ae1f
Source dataset
uspto-grants-2011_10
Patent number
US08039493B2

Reaction notes

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