HRID1665064

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID2773542

3-(Methylsulfonyl)phenylboronic acid

C7H9BO4S

结构：CC(C)CN(Cc1cccc(Br)c1)S(=O)(=O)c1ccccc1Cl

HCID67441490

未命名化合物

PRODUCTS

生成物

结构：CC(C)CN(Cc1cccc(-c2cccc(S(C)(=O)=O)c2)c1)S(=O)(=O)c1ccccc1Cl

HCID25234311

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：ClCCl.Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1

催化剂HCID178418807

未命名化合物

溶剂HCID21886435

1,4-Dioxane--water (1/1)

C4H10O3

PROCEDURE

实验过程

In analogy to example 1, step 3, N-(3-bromo-benzyl)-2-chloro-N-isobutyl-benzenesulfonamide was reacted with (3-methylsulfonylphenyl)-boronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give 2-chloro-N-isobutyl-N-(3′-methanesulfonyl-biphenyl-3-ylmethyl)-benzenesulfonamide as a colorless solid. MS: 550.2 ([M+OAc]−)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fa3ad884bc0545b482ca4eab2fddc203
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08039493B2
来源说明: uspto-grants-2011_10

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[CH2:5][N:6]([CH2:17][CH:18]([CH3:20])[CH3:19])[S:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16])(=[O:9])=[O:8].[CH3:24][S:25]([C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][CH:33]=1)(=[O:27])=[O:26].C([O-])([O-])=O.[Na+].[Na+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].ClCCl>[Cl:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[S:7]([N:6]([CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:5][C:4]1[CH:3]=[C:2]([C:32]2[CH:31]=[CH:30][CH:29]=[C:28]([S:25]([CH3:24])(=[O:27])=[O:26])[CH:33]=2)[CH:23]=[CH:22][CH:21]=1)(=[O:9])=[O:8]