HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-chloro-N-isobutyl-N-(3'-methanesulfonyl-biphenyl-3-ylmethyl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-(Methylsulfonyl)phenylboronic acid | HCID 2773542 | — |
| Reactant | N-(3-bromo-benzyl)-2-chloro-N-isobutyl-benzenesulfonamide | HCID 67441490 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | 2-chloro-N-isobutyl-N-(3'-methanesulfonyl-biphenyl-3-ylmethyl)-benzenesulfonamide | HCID 25234311 | — |
Reaction Steps
In analogy to example 1, step 3, N-(3-bromo-benzyl)-2-chloro-N-isobutyl-benzenesulfonamide was reacted with (3-methylsulfonylphenyl)-boronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give 2-chloro-N-isobutyl-N-(3′-methanesulfonyl-biphenyl-3-ylmethyl)-benzenesulfonamide as a colorless solid. MS: 550.2 ([M+OAc]−)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-fa3ad884bc0545b482ca4eab2fddc203 |
| Source note | uspto-grants-2011_10 |