HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylmethane sulfonyl chloride → C-cyclohexyl-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylmethane sulfonyl chloride | HCID 3871475 | — |
| Reactant | Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine | HCID 67441398 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | C-cyclohexyl-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-methanesulfonamide | HCID 25234325 | — |
Reaction Steps
In analogy to example 25, isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine (example 15, step 2) was reacted with cyclohexyl-methane-sulfonylchloride and dimethylketene-methyltrimethylsilylacetal in dichloromethane to give C-cyclohexyl-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-methanesulfonamide as an off-white solid. MS: 500.9 ([M+NH4]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039493B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-6cd57fde1c4f48efab2ced2800fa56d6 |
| Source note | uspto-grants-2011_10 |