Trifluoroacetic acid → HCID 67086938, compound

HRID 1665175Notes

Reaction equation

HRID 1665175 reaction equation
C([O:5][C:6](=[O:21])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:11][CH:10]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:20][O:19][C:17]([CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][C:6]([OH:21])=[O:5])=[CH:10][CH:11]=1)=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67086791HCID 67086791, compound

Product 1

HCID 67086938HCID 67086938, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 3-(4-Methoxycarbonylmethoxy-phenyl)-propionic acid tert-butyl ester (0.097 g, 0.33 mmol) is added a 90% solution of TFA in DCM (2 ml) and the resulting solution is stirred at room temperature for 1 hour. The solvents are removed in vacuo to yield 3-(4-Methoxycarbonylmethoxy-phenyl)-propionic acid as an off-white powder; [M+H-18]+ 256.0

Workup

  1. customThe solvents are removed in vacuo

Sources & evidence

ORD record
ord-89c412efdf0a4f26a1a74b29dd187a5a
Source dataset
uspto-grants-2011_10
Patent number
US08039472B2

Reaction notes

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