HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoic acid methyl ester | HCID 67150380 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoic acid | HCID 58271191 | 97.3% |
Reaction Steps
3-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-benzoic acid methyl ester (6.5 g, 16.92 mmol) and 2N KOH (33.84 mL, 67.68 mmol) in 100 mL MeOH were reacted as above to yield 6.1 g (97.4) of 3-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-benzoic acid. LC-MS (ES) calculated for C21H16F2O4, 370.36; found m/z 369 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039495B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-0ff31f842969452c90f774a34b8b04af |
| Source note | uspto-grants-2011_10 |