反应详情

A mixture of 3-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-benzoic acid (16.44 g, 44.39 mmol), toluene (180 mL), SOCl2 (19.4 mL, 265.8 mmol), and anhydrous DMF (1 mL) was heated to reflux overnight, cooled to room temperature, and evaporated to dryness. The residue was co-evaporated twice with toluene followed by high vacuum at 70° C. for 4 h to give 3-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-benzoyl chloride as a solid (17 g).

1. temperaturewas heated
2. temperatureto reflux overnight
3. customevaporated to dryness