4-Chlorophenylacetyl chloride → HCID 57661841, compound

HRID 1665283Notes

Reaction equation

HRID 1665283 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30](Cl)=[O:31])=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([N:1]2[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]2)=[O:31])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57661841HCID 57661841, compound

Procedure

Compound 47 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, (4-chlorophenyl)acetyl chloride and conditions outlined in procedure N. M.p.=120-125° C.; 300 MHz 1H NMR (DMSO-d6) δ 7.91 (m, 2H), 7.74 (t, 1H), 7.56 (t, 1H), 7.35 (m, 2H), 7.25 (m, 2H), 4.10 (dd, 1H), 3.94 (m, 1H), 3.77 (dd, J=3.3 Hz, 2H), 3.57 (s, 2H), 3.09 (s, 2H), 2.05 (m, 2H), 1.67 (m, 2H); LCMS: 454 [M+H].

Sources & evidence

ORD record
ord-c28e38cf6dbd44c8a3ef1db93d0865ed
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

Loading…