Benzoyl chloride, 3-chloro- → HCID 57662045, compound

HRID 1665297Notes

Reaction equation

HRID 1665297 reaction equation
[O:1]1[C:6]2([CH2:12][CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][S:4][C:3]2[C:13](=[O:22])[C:14](=[O:21])[C:15]3[C:20]([C:2]1=2)=[CH:19][CH:18]=[CH:17][CH:16]=3.[Cl:23][C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=1)[C:27](Cl)=[O:28]>>[Cl:23][C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=1)[C:27]([N:9]1[CH2:10][CH2:11][CH2:12][C:6]2([O:1][C:2]3[C:20]4[C:15]([C:14](=[O:21])[C:13](=[O:22])[C:3]=3[S:4][CH2:5]2)=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH2:7][CH2:8]1)=[O:28]

Participants

3

Reactant 2

HCID 69252Benzoyl chloride, 3-chloro-HCID 57661973HCID 57661973, compound

Product 1

HCID 57662045HCID 57662045, compound

Procedure

Compound 62 was synthesized using spiro[azepane-4,2′-naphtho[1,2-b][1,4]oxathiine]-5′,6′-dione, 3-chlorobenzoyl chloride and conditions outlined in procedure N. M.p.=98-100° C., 400 MHz 1H NMR (CDCl3) δ: 8.08-8.06 (m, 1H), 7.76-7.66 (m, 2H), 7.52-7.48 (m, 1H), 7.42-7.21 (m, 4H), 3.87-3.86 (m, 1H), 3.67-3.49 (m, 3H), 3.05-2.92 (m, 2H), 2.39-2.17 (m, 4H), 2.04-1.96 (m, 1H), 1.89-1.76 (m, 1H); LCMS: 454 [M+H].

Sources & evidence

ORD record
ord-79e1ff240af74bbead49ff7288d8cb9f
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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