3-Chlorobenzenesulphonyl chloride → HCID 57662050, compound

HRID 1665314Notes

Reaction equation

HRID 1665314 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[Cl:22][C:23]1[CH:24]=[C:25]([S:29](Cl)(=[O:31])=[O:30])[CH:26]=[CH:27][CH:28]=1>>[Cl:22][C:23]1[CH:24]=[C:25]([S:29]([N:1]2[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]2)(=[O:31])=[O:30])[CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 179093-Chlorobenzenesulphonyl chlorideHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57662050HCID 57662050, compound

Procedure

Compound 82 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 3-chlorobenzenesulfonyl chloride and conditions outlined in procedure P. M.p.=255-256° C.; 400 1H NMR (DMSO-d6) δ: 7.98-7.9 (m, 1H), 7.89-7.82 (m, 1H), 7.8-7.7 (m, 3H), 7.58-7.4 (m, 2H), 7.3 (d, J=7.6 Hz, 1H), 3.65-3.58 (m, 2H), 3.1 (s, 2H), 2.6-2.5 (m, 2H), 2.15-2.05 (m, 2H), 1.95-1.84 (m, 2H) LCMS: 476 [M+H].

Sources & evidence

ORD record
ord-5fe8cf7f9cfe4c34a8da50935720b63b
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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