HCID 53973062, compound → HCID 57661863, compound

HRID 1665348Notes

Reaction equation

HRID 1665348 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[F:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][CH2:32]I)=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][CH2:32][N:1]2[CH2:2][CH2:3][C:4]3([O:11][C:10]4[C:12]5[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=4[S:8][CH2:7]3)=[CH:16][CH:15]=[CH:14][CH:13]=5)[CH2:5][CH2:6]2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 53973062HCID 53973062, compoundHCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57661863HCID 57661863, compound

Procedure

Compound 151 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione and 1-fluoro-4-(3-iodopropoxy)benzene and conditions outlined in procedure V. M.p.=164-165° C.; 400 MHz 1H NMR (DMSO-d6) δ: 7.92-7.87 (m, 1H), 7.82-7.76 (m, 2H), 7.6-7.52 (m, 1H), 7.18-7.06 (m, 2H), 6.97-6.9 (m, 2H), 4.03-3.95 (m, 2H), 3.07 (s, 2H), 2.82-2.72 (m, 2H), 2.55-2.48 (m, 2H), 2.4-2.25 (m, 2H), 2.05-1.75 (m, 6H); LCMS: 454 [M+H].

Sources & evidence

ORD record
ord-808f6e29a5914884a586cd58f83135b7
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

Loading…