4-(2,3-Epoxypropyl)morpholine → HCID 57661892, compound

Participants

Reaction Steps

Compound 166 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, 4-(oxiran-2-ylmethyl)morpholine and conditions outlined in procedure X. M.P.=75-78° C.; 400 MHz 1H NMR (CDCl3) δ: 8.05 (d, 1H), 7.75 (d, 1H), 7.65 (t, 1H), 7.5 (t, 1H), 3.9 (m, 1H), 3.7 (m, 5H), 2.95 (s, 1H), 2.9 (t, 2H), 2.7-2.3 (m, 11H), 2.15 (d, 2H), 1.9 (q, 2H); LCMS: 445 [M+H].

Provenance & Evidence