129098-61-9 → HCID 57661967, compound

HRID 1665412Notes

Reaction equation

HRID 1665412 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:3][CH2:2]1.[CH:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:23]=1[O:32][CH2:33][C@@H:34]1[CH2:36][O:35]1>>[OH:35][C@H:34]([CH2:33][O:32][C:23]1[CH:24]=[CH:25][C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:22]=1)[CH2:36][N:1]1[CH2:2][CH2:3][C:4]2([O:11][C:10]3[C:12]4[C:17]([C:18](=[O:21])[C:19](=[O:20])[C:9]=3[S:8][CH2:7]2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 726163129098-61-9HCID 57661820Spiro[naphtho[1,2-b][1,4]oxathiine-2,4'-piperidine]-5,6-dione

Product 1

HCID 57661967HCID 57661967, compound

Procedure

Compound 221 was synthesized using spiro[naphtho[1,2-b][1,4]oxathiine-2,4′-piperidine]-5,6-dione, (2S)-2-[(2-naphthyloxy)methyl]oxirane and conditions outlined in procedure Y. M.p.=164-167° C., (DMSO-d6) δ: 7.91-7.87 (m, 1H), 7.84-7.78 (m, 5H), 7.6-7.52 (m, 1H), 7.48-7.4 (m, 1H), 7.38-7.3 (m, 2H), 7.2-7.14 (m, 1H), 5.0-4.93 (m, 1H), 4.2-3.97 (m, 3H), 3.07 (s, 2H), 2.93-2.76 (m, 2H), 2.63-2.4 (m, 4H), 2.06-1.93 (m, 2H), 1.9-1.78 (m, 2H); LCMS=502 [M+H].

Sources & evidence

ORD record
ord-9d0e3f83da414b30916a709e2e1399d3
Source dataset
uspto-grants-2011_10
Patent number
US08039503B2

Reaction notes

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