反应详情

2-(2-Fluorophenyl)ethanol (Ald, 1.0 g) was dissolved in dichloromethane (KANTO, 20 mL) under nitrogen atmosphere and added with Dess-Martin reagent (Alfa Aesar, 3.64 g), followed by stirring at room temperature for 3 hours. Saturated sodium thiosulfate solution was added to the reaction mixture and then extracted with ethyl acetate. The organic layer was washed with saturated sodium hydrogencarbonate solution and brine, and then dried over anhydrous magnesium sulfate. The reaction solution was concentrated under reduced pressure to obtain the target compound as a crude product.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with saturated sodium hydrogencarbonate solution and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationThe reaction solution was concentrated under reduced pressure