1-Methylpiperazine → HCID 44517288, compound

HRID 1665506Notes

Reaction equation

C[C:2]1[CH:10]=[C:9]([NH:11][C:12](=[O:36])[NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:25]=[C:24]([O:26][CH:27]([CH3:29])[CH3:28])[N:23]=[C:22]([N:30]4[CH2:35][CH2:34][O:33][CH2:32][CH2:31]4)[N:21]=3)=[CH:16][CH:15]=2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:37][N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1>>[CH:27]([O:26][C:24]1[N:23]=[C:22]([N:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)[N:21]=[C:20]([C:17]2[CH:16]=[CH:15][C:14]([NH:13][C:12]([NH:11][C:9]3[CH:8]=[CH:7][C:3]([C:4]([N:41]4[CH2:42][CH2:43][N:38]([CH3:37])[CH2:39][CH2:40]4)=[O:6])=[CH:2][CH:10]=3)=[O:36])=[CH:19][CH:18]=2)[N:25]=1)([CH3:28])[CH3:29]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 67021897HCID 67021897, compound

Product 1

HCID 44517288HCID 44517288, compoundYield 44%

Procedure

Starting from methyl 4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzoic acid (160 mg, 0.33 mmol) and 4-methylpiperazine following the procedure as outlined in Experimental 71, 80 mg (44% Yield) of the titled compound was isolated as white solid. MS (ESI) m/z 281.2.

Sources & evidence

ORD record: ord-efc1b24503784bb89fc942f8dd0eef60
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08039469B2

Reaction notes

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