Trifluoroacetic acid → Trifluoroacetic acid

HRID 1665531Notes

Reaction equation

HRID 1665531 reaction equation
[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)=[O:23])=[CH:17][CH:16]=3)[N:12]=[C:11]([N:31]3[CH2:36][CH2:35][CH:34]([NH:37][CH2:38][C:39]([O:41]C(C)(C)C)=[O:40])[CH2:33][CH2:32]3)[N:10]=1)[CH2:2]2.[F:46][C:47]([F:52])([F:51])[C:48]([OH:50])=[O:49]>ClCCl>[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([C:15]3[CH:16]=[CH:17][C:18]([NH:21][C:22]([NH:24][C:25]4[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=4)=[O:23])=[CH:19][CH:20]=3)[N:12]=[C:11]([N:31]3[CH2:36][CH2:35][CH:34]([NH:37][CH2:38][C:39]([OH:41])=[O:40])[CH2:33][CH2:32]3)[N:10]=1)[CH2:2]2.[C:48]([OH:50])([C:47]([F:52])([F:51])[F:46])=[O:49]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67021916HCID 67021916, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 67021900HCID 67021900, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 2-(1-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-(3-pyridin-4-ylureido)phenyl)-1,3,5-triazin-2-yl)piperidin-4-ylamino)acetate (28 mg) in dichloromethane (3 mL) was treated with trifluoroacetic acid (1 mL) and then concentrated to dryness to give the title compound as its TFA salt.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-9820c24e58654f4899e0891a1a38bb34
Source dataset
uspto-grants-2011_10
Patent number
US08039469B2

Reaction notes

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