Hydrochloric Acid → HCID 87080405, compound

Participants

Reaction Steps

A solution of 4-(2,5-dichloro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (390 mg, 1.08 mmol) in 1,4-dioxane (1 mL) was cooled to 0° C. Dioxane.HCl (1 mL) was then added and the resulting mixture stirred for 15 minutes. The reaction mixture was then concentrated under reduced pressure to afford a solid, which was washed with ether and dried to afford 313 mg (97%) of 4-(2,5-dichloro-phenyl)-piperazin-1-yl-methanone.hydrochloride, LCMS: 296.01 (M+1)+, 96.09%.

Provenance & Evidence