Hydrochloric Acid → HCID 87080405, compound

HRID 1665581Notes

Reaction equation

HRID 1665581 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=O)[C:15]2C=[C:19]([Cl:21])[CH:18]=[CH:17][C:16]=2[Cl:22])[CH2:10][CH2:9]1)=[O:7])(C)(C)C.Cl>O1CCOCC1>[ClH:21].[Cl:21][C:19]1[CH:18]=[CH:17][C:16]([Cl:22])=[CH:15][C:14]=1[N:11]1[CH2:10][CH2:9][N:8]([CH:6]=[O:7])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 17480368HCID 17480368, compound

Product 1

HCID 87080405HCID 87080405, compoundYield 196.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 4-(2,5-dichloro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (390 mg, 1.08 mmol) in 1,4-dioxane (1 mL) was cooled to 0° C. Dioxane.HCl (1 mL) was then added and the resulting mixture stirred for 15 minutes. The reaction mixture was then concentrated under reduced pressure to afford a solid, which was washed with ether and dried to afford 313 mg (97%) of 4-(2,5-dichloro-phenyl)-piperazin-1-yl-methanone.hydrochloride, LCMS: 296.01 (M+1)+, 96.09%.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customto afford a solid, which
  3. washwas washed with ether
  4. customdried

Sources & evidence

ORD record
ord-f6bd0fc045e3461698b303c5087925cd
Source dataset
uspto-grants-2011_10
Patent number
US08039463B2

Reaction notes

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