Hydrochloric Acid → (2-Trifluoromethyl-5-fluoro-phenyl)-piperazin-1-yl-methanone hydrochloride

HRID 1665583Notes

Reaction equation

HRID 1665583 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=2[C:22]([F:25])([F:24])[F:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[F:21][C:19]1[CH:18]=[CH:17][C:16]([C:22]([F:25])([F:23])[F:24])=[C:15]([C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:26])[CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 578758004-(5-Fluoro-2-trifluoromethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 66625607(2-Trifluoromethyl-5-fluoro-phenyl)-piperazin-1-yl-methanone hydrochlorideYield 89%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A stirred solution of 4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (295 mg, 0.78 mmol) in dioxane was cooled to 0° C. and dioxane.HCl (1 mL) was added. The reaction mixture was stirred for 15 minutes, then concentrated. The resulting solid was washed with diethyl ether and dried to afford 220 mg (89%) of (5-fluoro-2-trifluoromethyl-phenyl)-piperazin-1-yl methanone hydrochloride, LCMS: 313.07 (M+1)+, 97.2%. Intermediate-3

Workup

  1. concentrationconcentrated
  2. washThe resulting solid was washed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-cec8461f1d7e41edb251f4644aff6cf5
Source dataset
uspto-grants-2011_10
Patent number
US08039463B2

Reaction notes

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