Hydrochloric Acid → 1-(2-Trifluoromethylbenzoyl)piperazine hydrochloride

HRID 1665588Notes

Reaction equation

HRID 1665588 reaction equation
[N:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:18])([F:17])[F:16])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[ClH:19]>C(OCC)C>[ClH:19].[N:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:17])([F:16])[F:18])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazine

Product 1

HCID 167337831-(2-Trifluoromethylbenzoyl)piperazine hydrochlorideYield 91%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of piperazin-1-yl-(2-trifluoromethyl-phenyl)-methanone (5.5 g, 21.4 mmol) in diethylether.HCl was stirred at 0° C. for 30 minutes. The mixture was then concentrated, and the resulting residue washed with benzene and dried to afford 5.7 g (91%) of piperazin-1-yl-(2-trifluoromethyl-phenyl)-methanone hydrochloride. 1H NMR: (DMSO-d6): δ 9.6 (s, 2H), 7.8 (m, 2H), 7.6 (m, 2H), 4.0 (m, 1H), 3.8 (m, 1H), 3.0 (m, 1H), 3.4 (m, 2H), 3.1 (m, 3H), 2.9 (m, 1H).

Workup

  1. concentrationThe mixture was then concentrated
  2. washthe resulting residue washed with benzene
  3. customdried

Sources & evidence

ORD record
ord-9a4db6f387f04464bbe0fa5845bb4931
Source dataset
uspto-grants-2011_10
Patent number
US08039463B2

Reaction notes

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