HCID 57875821, compound → HCID 57875798, compound

HRID 1665590Notes

Reaction equation

HRID 1665590 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[C:18]([F:24])[CH:17]=2)=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[N:11]1([C:14]([C:16]2[CH:17]=[C:18]([F:24])[C:19]([F:23])=[C:20]([F:22])[CH:21]=2)=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 57875821HCID 57875821, compound

Product 1

HCID 57875798HCID 57875798, compoundYield 102.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10% Pd/C (80 mg) was added to a stirred solution of (4-benzyl-piperazin-1-yl)-(3,4,5-trifluoro-phenyl)-methanone (800 mg, 2.4 mmol) in methanol (20 mL) and the mixture was stirred under an atmosphere of hydrogen for 6 hours. The mixture was then filtered over celite and the filtrate concentrated to afford 600 mg (95%) of piperazin-1-yl-(3,4,5-trifluoro-phenyl)-methanone. LCMS: 245.09 (M+1)+, 92.4%

Workup

  1. filtrationThe mixture was then filtered over celite
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-6a9c60e3a7cb49b5bb2e6cf3a323a2b4
Source dataset
uspto-grants-2011_10
Patent number
US08039463B2

Reaction notes

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