Hydrochloric Acid → N-Biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride

Participants

Reaction Steps

HCl (10 mL) was added to 4-[2-(biphenyl-4-ylcarbamoyl)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester (1.3 g, 3.1 mmol) and the resulting mixture was stirred for 30 minutes, then concentrated. The residue was washed with diethyl ether and dried to afford 1.0 g (90%) of N-Biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride

Provenance & Evidence