Hydrochloric Acid → N-Biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride

HRID 1665596Notes

Reaction equation

HRID 1665596 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:31])[CH2:15][C:16](=[O:30])[NH:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>>[ClH:32].[C:21]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:20]=[CH:19][C:18]([NH:17][C:16](=[O:30])[CH2:15][C:14](=[O:31])[N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 578758074-[2-(Biphenyl-4-ylcarbamoyl)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 66625265N-Biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochlorideYield 90%

Procedure

HCl (10 mL) was added to 4-[2-(biphenyl-4-ylcarbamoyl)-acetyl]-piperazine-1-carboxylic acid tert-butyl ester (1.3 g, 3.1 mmol) and the resulting mixture was stirred for 30 minutes, then concentrated. The residue was washed with diethyl ether and dried to afford 1.0 g (90%) of N-Biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride

Workup

  1. concentrationconcentrated
  2. washThe residue was washed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-faefe5eb810041108f0ec9f02de631e7
Source dataset
uspto-grants-2011_10
Patent number
US08039463B2

Reaction notes

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