反应详情

A solution of 4-(3-cyano-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (590 mg, 1.87 mmol) in 1,4-dioxane.HCl (3 mL) was stirred at 0° C. for 1 hour. The reaction mixture was then concentrated under reduced pressure and the resulting residue was washed with ether and dried to afford 350 mg (75%) of (3-cyano-phenyl)-piperazin-1-yl-methanone.hydrochloride.

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. washthe resulting residue was washed with ether
3. customdried