Hydrochloric Acid → (3-Cyano-phenyl)-piperazin-1-yl-methanone.hydrochloride

HRID 1665666Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1665666
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:23])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[N:22])[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[C:21]([C:17]1[CH:16]=[C:15]([C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:23])[CH:20]=[CH:19][CH:18]=1)#[N:22]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 31517243Tert-butyl 4-(3-cyanobenzoyl)piperazine-1-carboxylate

Produkt 1

HCID 66625398(3-Cyano-phenyl)-piperazin-1-yl-methanone.hydrochlorideAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 4-(3-cyano-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (590 mg, 1.87 mmol) in 1,4-dioxane.HCl (3 mL) was stirred at 0° C. for 1 hour. The reaction mixture was then concentrated under reduced pressure and the resulting residue was washed with ether and dried to afford 350 mg (75%) of (3-cyano-phenyl)-piperazin-1-yl-methanone.hydrochloride.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. washthe resulting residue was washed with ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-40053b9de75d46c89dad9a36293a0af1
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08039463B2

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