HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3-Cyano-phenyl)-piperazin-1-yl-methanone.hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(3-cyanobenzoyl)piperazine-1-carboxylate | HCID 31517243 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3-Cyano-phenyl)-piperazin-1-yl-methanone.hydrochloride | HCID 66625398 | 75% |
Reaction Steps
A solution of 4-(3-cyano-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (590 mg, 1.87 mmol) in 1,4-dioxane.HCl (3 mL) was stirred at 0° C. for 1 hour. The reaction mixture was then concentrated under reduced pressure and the resulting residue was washed with ether and dried to afford 350 mg (75%) of (3-cyano-phenyl)-piperazin-1-yl-methanone.hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08039463B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-40053b9de75d46c89dad9a36293a0af1 |
| Source note | uspto-grants-2011_10 |