反应详情

KOH (386 mg, 6.88 mmol) was added to a solution 2-methyl-malonic acid diethyl ester (1 g, 5.74 mmol) in methanol (7 mL). The resulting mixture was stirred overnight at ambient temperature then concentrated. The resulting residue was diluted with water, acidified with conc. HCl and the product was extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 360 mg (47%) of 2-methyl-malonic acid monomethyl ester

1. concentrationthen concentrated
2. additionThe resulting residue was diluted with water
3. extractionthe product was extracted with dichloromethane
4. dry with materialThe organic layer was dried over sodium sulfate
5. concentrationconcentrated under reduced pressure