1,1'-(Chlorophenylmethylene)bis(4-methoxybenzene) → HCID 86638307, compound

HRID 1665824Notes

Reaction equation

HRID 1665824 reaction equation
[C:1]([N:9]1[C:33](=[O:34])[CH:32]=[CH:31][N:11]([C@@H:12]2[O:30][C@H:27]([CH2:28][OH:29])[C@@H:25]([OH:26])[C@H:13]2[O:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[O:18])[C:10]1=[O:35])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:36][O:37][C:38]1[CH:59]=[CH:58][C:41]([C:42](Cl)([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)[C:43]2[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][CH:44]=2)=[CH:40][CH:39]=1>N1C=CC=CC=1>[C:1]([N:9]1[C:33](=[O:34])[CH:32]=[CH:31][N:11]([C@@H:12]2[O:30][C@H:27]([CH2:28][O:29][C:42]([C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)([C:43]3[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][CH:44]=3)[C:41]3[CH:40]=[CH:39][C:38]([O:37][CH3:36])=[CH:59][CH:58]=3)[C@@H:25]([OH:26])[C@H:13]2[O:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[O:18])[C:10]1=[O:35])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 968311,1'-(Chlorophenylmethylene)bis(4-methoxybenzene)HCID 86638308HCID 86638308, compound

Product 1

HCID 86638307HCID 86638307, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The N3-benzoyl-2′-O-[2-(2,2,2-trifluoroethoxy)carbonylethyl]uridine (750 mg, 1.5 mmol) synthesized in Example 14 was dissolved in dried pyridine (15 mL). To the solution was added 4,4′-dimethoxytrityl chloride (763 mg, 2.3 mmol), followed by stirring at room temperature for 1.5 hours. The reaction was terminated by adding water thereto. The solvent was evaporated under reduced pressure, and the residue was subjected to silica gel column chromatography eluting with hexane-chloroform (1:1, v/v) to give the title compound as a white foam-like material (750 mg, 62%).

Workup

  1. customThe reaction was terminated
  2. additionby adding water
  3. customThe solvent was evaporated under reduced pressure
  4. washeluting with hexane-chloroform (1:1

Sources & evidence

ORD record
ord-308cd225206d4bf5aced782c02fae9cc
Source dataset
uspto-grants-2011_10
Patent number
US08039611B2

Reaction notes

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