反应详情

温度

75 °C

Alternative preparation of Benzyl (R)-2-((S)-2,5-dihydrofuran-2-yl)-2-hydroxyethylcarbamate (18); ‘One-pot’ procedure 3; Aqueous Conditions. (S)-1-((S)-2,5-Dihydrofuran-2-yl)-2-hydroxyethyl 4-methylbenzenesulfonate (14) (0.95 g, 3.35 mmol) was suspended in ammonium hydroxide (4 mL) then stirred and heated at 75° C. in a sealed tube for 6 hours during which time the two liquid phases became a single phase solution. The mixture was stirred at ambient temperature for 20 hours then the solvents were removed in vacuo. The residue was azeotroped with diethyl ether (3×10 mL) to obtain (R)-2-amino-1-((S)-2,5-dihydrofuran-2-yl)ethanol which was used without further purification.

1. stirringThe mixture was stirred at ambient temperature for 20 hours
2. customthe solvents were removed in vacuo
3. customThe residue was azeotroped with diethyl ether (3×10 mL)