Hydrochloric Acid → HCID 67442415, compound

HRID 1665875Notes

Reaction equation

HRID 1665875 reaction equation
[OH:1][C@@H:2]1[C@H:6]2[N:7](C(OCC3C4C=CC=CC=4C4C3=CC=CC=4)=O)[CH2:8][C@H:9]([S:10][CH3:11])[C@H:5]2[O:4][CH2:3]1.Cl.O[C@@H]1[C@H]2N(C(OC(C)(C)C)=O)C[C@H](SC)[C@H]2OC1>O1CCOCC1>[CH3:11][S:10][C@H:9]1[CH2:8][NH:7][C@@H:6]2[C@@H:2]([OH:1])[CH2:3][O:4][C@H:5]12

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 67439721HCID 67439721, compoundHCID 67441663HCID 67441663, compound

Product 1

HCID 67442415HCID 67442415, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of (3R,3aR,6S,6aS)(9H-fluoren-9-yl)methyl 3-hydroxy-6-(methylthio)tetrahydro-2H-furo[3,2-b]pyrrole-4(5H)-carboxylate (55) A solution of HCl in 1,4-dioxane (4M, 5.5 mL) was added to thiomethylether (54) (152 mg, 0.55 mmol). The mixture stirred for 1 hour then the solvents removed in vacuo. The residue was azeotroped with CH3CN (5 mL) to obtain (3R,3aR,6S,6aS)-6-(methylthio)hexahydro-2H-furo[3,2-b]pyrrol-3-ol which was used without further purification.

Workup

  1. customthe solvents removed in vacuo
  2. customThe residue was azeotroped with CH3CN (5 mL)

Sources & evidence

ORD record
ord-201d49eb562b43d99282e62473d7cb08
Source dataset
uspto-grants-2011_10
Patent number
US08039641B2

Reaction notes

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