HuagongsheHuagongshe Chemistry Print Report · For research reference only
Neopentylamine → 3-[5-Cyano-6-(2,2-dimethyl-propylamino)-3-fluoro-pyridin-2-ylamino]-N-methoxy-4-methyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Neopentylamine | HCID 79882 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | 3-(6-chloro-5-cyano-3-fluoro-pyridin-2-ylamino)-N-methoxy-4-methyl-benzamide | HCID 86588800 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-[5-Cyano-6-(2,2-dimethyl-propylamino)-3-fluoro-pyridin-2-ylamino]-N-methoxy-4-methyl-benzamide | HCID 10178137 | 1.8% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
A mixture of 3-(6-chloro-5-cyano-3-fluoro-pyridin-2-ylamino)-N-methoxy-4-methyl-benzamide (52 mg, 0.15 mmol), neopentylamine (0.12 mL) and potassium fluoride (12 mg) in DMSO (1 mL) was heated to 150° C. overnight. The product (1.1 mg, 1.8%) was isolated after purification by HPLC. C20H24FN5O2 MS m/e=386 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044040B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-6310500492ab4839aa862b546139f09a |
| Source note | uspto-grants-2011_10 |