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HRID1666068

反应详情

EQUATION

反应方程式

HRID 1666068 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)CN
HCID79882

2,2-Dimethyl-1-propylamine

C5H13N

结构：[F-].[K+]
HCID522689

Potassium fluoride

FK

结构：CONC(=O)c1ccc(C)c(Nc2nc(Cl)c(C#N)cc2F)c1
HCID86588800

未命名化合物

PRODUCTS

生成物

1
结构：CONC(=O)c1ccc(C)c(Nc2nc(NCC(C)(C)C)c(C#N)cc2F)c1
HCID10178137

未命名化合物

收率 1.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

CONDITIONS

反应条件

温度
150 °C

PROCEDURE

实验过程

A mixture of 3-(6-chloro-5-cyano-3-fluoro-pyridin-2-ylamino)-N-methoxy-4-methyl-benzamide (52 mg, 0.15 mmol), neopentylamine (0.12 mL) and potassium fluoride (12 mg) in DMSO (1 mL) was heated to 150° C. overnight. The product (1.1 mg, 1.8%) was isolated after purification by HPLC. C20H24FN5O2 MS m/e=386 (M+H).