Methylamine → HCID 10157541, compound

HRID 1666071Notes

Reaction equation

[C:1]([C:3]1[C:4]([NH:20][C:21]2[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=2[CH3:31])[C:24]([NH:26][CH3:27])=[O:25])=[N:5][C:6](S(C)(=O)=O)=[N:7][C:8]=1[N:9]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])#[N:2].[CH3:32][NH2:33]>O1CCOCC1>[C:1]([C:3]1[C:4]([NH:20][C:21]2[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=2[CH3:31])[C:24]([NH:26][CH3:27])=[O:25])=[N:5][C:6]([NH:33][CH3:32])=[N:7][C:8]=1[N:9]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])#[N:2]

Participants

Conditions

Temperature: 80 °C

Procedure

3-{5-Cyano-6-[(2,2-dimethyl-propyl)-methyl-amino]-2-methanesulfonyl-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide (44 mg, 0.1 mmol) and methylamine (1 mL, 1M in THF) were mixed in p-dioxane (1 mL) in a sealed tube. The mixture was heated to 80° C. for overnight. The solvent was removed in vacuo, and the product (23 mg) was purified by the silica gel column chromatography. MS (m/z): 396 (M+H).

Workup

customThe solvent was removed in vacuo
customthe product (23 mg) was purified by the silica gel column chromatography

Sources & evidence

ORD record: ord-de363e032862464b99999ee95b5ff130
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08044040B2

Reaction notes

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