HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloro-5-nitropyrimidine → (6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2,2-Dimethylpropyl)(methyl)amine hydrochloride | HCID 22393520 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine | HCID 58928507 | — |
Reaction Steps
4,6-Dichloro-5-nitro-pyrimidine (0.20 g, 1.0 mmol), N-methyl-neopentylamine hydrochloride (0.14 g) and DIEA (0.2 mL) were stirred in acetone (5 mL) at 0° C. for 4 hours. The solvent was removed in vacuo and the crude product was used for the next reaction without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044040B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-9237ff53af49440f9edf0e8470505c51 |
| Source note | uspto-grants-2011_10 |