4,6-Dichloro-5-nitropyrimidine → (6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine

HRID 1666092Notes

Reaction equation

HRID 1666092 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.Cl.[CH3:13][NH:14][CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17].CCN(C(C)C)C(C)C>CC(C)=O>[Cl:11][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:14]([CH2:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH3:13])[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 203124,6-Dichloro-5-nitropyrimidineHCID 81531DiisopropylethylamineHCID 22393520(2,2-Dimethylpropyl)(methyl)amine hydrochloride

Product 1

HCID 58928507(6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4,6-Dichloro-5-nitro-pyrimidine (0.20 g, 1.0 mmol), N-methyl-neopentylamine hydrochloride (0.14 g) and DIEA (0.2 mL) were stirred in acetone (5 mL) at 0° C. for 4 hours. The solvent was removed in vacuo and the crude product was used for the next reaction without purification.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe crude product was used for the next reaction without purification

Sources & evidence

ORD record
ord-9237ff53af49440f9edf0e8470505c51
Source dataset
uspto-grants-2011_10
Patent number
US08044040B2

Reaction notes

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