Hydrochloric Acid → 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 166610Notes

Reaction equation

HRID 166610 reaction equation
[ClH:44].[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:31]1[CH2:32][CH2:33][N:34]([C:37]([O:38][C:39]([CH3:40])([CH3:41])[CH3:42])=[O:43])[CH2:35][CH2:36]1)[cH:9][c:10]2-[c:11]1[cH:12][c:13]2[c:17]([cH:18][cH:19]1)[N:16]([C:20]([CH2:21][c:22]1[c:23]([F:29])[cH:24][cH:25][c:26]([F:28])[cH:27]1)=[O:30])[CH2:15][CH2:14]2.[O:45]1[CH2:46][CH2:47][O:48][CH2:49][CH2:50]1>>[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:31]1[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]1)[cH:9][c:10]2-[c:11]1[cH:12][c:13]2[c:17]([cH:18][cH:19]1)[N:16]([C:20]([CH2:21][c:22]1[c:23]([F:29])[cH:24][cH:25][c:26]([F:28])[cH:27]1)=[O:30])[CH2:15][CH2:14]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668236061,1-dimethylethyl 4-(4-amino-5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate

Product 1

HCID 668236445-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-8996690060f14a68a21014f278da6e97
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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