HCID 44224964, compound → HCID 44224963, compound

HRID 1666193Notes

Reaction equation

HRID 1666193 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([CH2:21][NH2:22])[CH2:9]2)=[CH:4][CH:3]=1>C(OCC)C.Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([CH2:21][NH2:22])[CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 44224964HCID 44224964, compound

Product 1

HCID 44224963HCID 44224963, compoundYield 182.1%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of [5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-yl]methyl amine (19.33 g, 0.0545 mol) in diethylether (100 mL) and hydrogen chloride [2.0 M in diethyl ether (100 mL)] was stirred for 24 hours at room temperature and the solid formed was filtered off, washed with diethylether and dried to yield the [5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-yl]methyl amine hydrochloride (19.41 g, 91%) as a yellow solid.

Workup

  1. customthe solid formed
  2. filtrationwas filtered off
  3. washwashed with diethylether
  4. customdried

Sources & evidence

ORD record
ord-70502dba108848bba60e9da37ae13ab2
Source dataset
uspto-grants-2011_10
Patent number
US08044053B2

Reaction notes

Loading…