5-Fluoro-2-methylbenzenesulphonyl chloride → HCID 67442564, compound

HRID 1666195Notes

Reaction equation

[ClH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=3[Cl:21])[N:12]=[C:11]([CH2:22][NH2:23])[CH2:10]2)=[CH:5][CH:4]=1.[F:24][C:25]1[CH:26]=[CH:27][C:28]([CH3:35])=[C:29]([S:31](Cl)(=[O:33])=[O:32])[CH:30]=1>>[Cl:1][C:28]1([CH3:35])[CH:27]=[CH:26][C:25]([F:24])=[CH:30][CH:29]1[S:31]([NH:23][CH2:22][C:11]1[CH2:10][CH:9]([C:6]2[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=2)[N:13]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])[N:12]=1)(=[O:33])=[O:32]

Participants

Reactant 2

HCID 1362865-Fluoro-2-methylbenzenesulphonyl chloride

HCID 44224963HCID 44224963, compound

Product 1

HCID 67442564HCID 67442564, compoundYield 88%

Procedure

According to general sulfonamide coupling procedure, [5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-yl]methyl amine hydrochloride was reacted with 5-fluoro-2-methylbenzenesulfonyl chloride. The reaction yield was 88% of 2-Chloro-N-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-ylmethyl]-5-fluoro-2-methyl-benzenesulfonamide as a solid.

Sources & evidence

ORD record: ord-ed8c4265ee2046b7974fca89811d0754
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08044053B2

Reaction notes

Loading…